Tua Tagovailoa left the Miami Dolphins' 35-0 loss against the Buffalo Bills on Sunday after taking a hit in the first quarter.
Tagovailoa threw incomplete on fourth-and-2 and was hit by Bills defensive end A.J. Epenesa. The quarterback remained on the ground until Dolphins staffers helped him make his way to the sideline. He was later carted to the locker room.
Tagovailoa was ruled questionable to return with a rib injury and later declared out for the rest of the contest.
Jacoby Brissett replaced him in the game and completed 24 of 40 passes for 169 yards and an interception. Brissett also took four sacks.
Tagovailoa completed one of four passes for 13 yards before exiting. He faced consistent pressure early and took two sacks.
The No. 5 overall pick in the 2020 NFL draft, Tagovailoa received head coach Brian Flores' backing this offseason even amid persistent speculation that the team could look to acquire Houston Texans quarterback Deshaun Watson.
Tagovailoa saw his college career at Alabama come to an early end when he suffered a dislocated hip and fractured posterior wall.
He started nine games as a rookie after taking the reins from veteran Ryan Fitzpatrick midway through the year.
Follow Michael Middlehurst-Schwartz on Twitter @MikeMSchwartz.