Update 7:45 p.m.: A winter storm warning is in effect until 7 p.m. Thursday for Adams and Scioto counties, according to the National Weather Service.
Heave mixed precipitation will continue throughout the evening and 2 to 4 inches of snow and ice is possible, officials said.
The National Weather Service strongly discourages traveling at this time.
"If you must travel, keep an extra flashlight, food, and water in your vehicle in case of an emergency," officials said.
The winter storm warning is also in effect for parts of Kentucky, officials said.
Update 6:45 p.m.: Cincinnati Police are escorting a surgeon with donor organs from Cincinnati/Northern Kentucky International Airport to Cincinnati Children's Hospital during the snowstorm, officials said.
Roadways are hazardous with blowing and drifting snow and ice, police said. Traffic is moving very slowly and multiple roadways are impassable, including Vine Street from Jefferson to Mitchell avenues, Westwood Northern Boulevard west of Beekman Street, Warsaw Avenue, Glenway Avenue and Anderson Ferry Road.
The University of Cincinnati announced it will close from 5:30 p.m. until midnight Wednesday, although all online class instruction and learning will continue as scheduled.
Xavier University will also close Wednesday evening due to inclement weather, officials said.
"All evening classes are canceled," Xavier University wrote on Twitter. "Please avoid all unnecessary travel and be safe out there, Musketeers."
Update 5:30 p.m.: The Hamilton County Sheriff's Office issued a Level 1 snow alert for the county after 5 p.m., and Boone County issued a Level 2 snow emergency.
The winter weather advisory for Cincinnati, Hamilton and parts of Indiana is now in effect until 7 p.m. Thursday, forecasters say. The National Weather Service predicts additional snow accumulations of up to one inch and a light glaze of ice.
Update 5 p.m.: A mix of snow and freezing rain will cause "major problems" for the evening rush hour, officials said Wednesday – and Cincinnati is the "biggest problem area" in the state.
"Approaching 1,000 crews out across the state. Biggest problem area is without a doubt Cincinnati where heavy snow hit just as the PM commute was starting," the Ohio Department of Transportation tweeted Wednesday evening.
The wintry mix is "overspreading the Tri-State" and precipitation will spread to Maysville and Portsmouth, according to the National Weather Service.
Officials are encouraging drivers to slow down and use caution while traveling.
"Plan on slippery road conditions. The hazardous conditions could impact the morning or evening commute," officials said.
City of Cincinnati officials say crews are out on primary routes now clearing roadways.
"Please take it slow and exercise caution during your evening commute," city officials said.
Update 1 p.m.: Forecasters are still calling for ice accumulations of up to two-tenths of an inch, along with snow accumulations of 1 to 2 inches in Greater Cincinnati.
Forecasters said this will lead to hazardous driving conditions through the evening hours.
A winter weather advisory is in effect for Northern Kentucky and Clermont County through midnight Thursday due to expected snow and ice accumulation. Switzerland County, Indiana, is also included in the advisory.
Hamilton, Warren and Butler counties have not been added to the advisory as of 1 p.m.
"A winter weather event will unfold today and tonight, with mixed wintry precipitation near and south of the Ohio River and light snow north of the river," forecasters said.
Ice accumulations will be high for areas of Kentucky to the south of Cincinnati. Some areas of southern Kentucky could get half an inch of ice accumulations.
Previous reporting: After a whopping snowfall earlier this week, road conditions could still be less than stellar in Greater Cincinnati for Wednesday's commute.
Light snow, which may briefly mix with freezing rain or freezing drizzle, will move into the area during early and mid-morning hours, according to the National Weather Service in Wilmington.
Additional snow and ice accumulations will be light. The precipitation is expected to be mostly snow in Cincinnati and north and freezing rain in Northern Kentucky.
However, the light precipitation will likely produce slick spots on roads, bridges, and other surfaces due to cold ground temperatures.
A winter weather advisory is in effect for Northern Kentucky and Clermont County through midnight Thursday due to expected snow and ice accumulation. Switzerland County, Indiana is also included in the advisory.
Total snow accumulations of up to two inches and ice accumulations of up to one-tenth of an inch are possible.
"Plan on slippery road conditions. The hazardous conditions could impact the morning or evening commute," officials said. "Slow down and use caution while traveling."
You might hate the snow now but up next is bitter cold thanks to (you guessed it) the polar vortex.
Drier and colder conditions are expected later in the week and into the weekend, with daytime highs in the teens and negative temperatures possible overnight. We could also see some light snow on Saturday.
The National Weather Service said the coldest temperatures will be Sunday into Monday.
"There is the potential for much of the area to drop below zero Sunday night and wind chill to reach advisory levels," forecasters said.
Wednesday: Patchy snow and freezing drizzle before 9 a.m., then snow between 9 a.m. and 2 p.m., then freezing rain likely after 2 p.m. High near 28. Little or no ice accumulation expected. Total daytime snow accumulation of less than a half-inch possible. Overnight patchy snow and freezing drizzle. Cloudy, with a low around 20. New snow accumulation of less than a half-inch possible.
Thursday: A chance of snow before 3 p.m., then patchy snow and freezing drizzle between 3 p.m. and 4 p.m., then a chance of snow after 4 p.m. Mostly cloudy, with a high near 27. New snow accumulation of less than a half-inch possible. Overnight there is a slight chance of snow before 8 p.m. Cloudy, with a low around 18.
Friday: Partly sunny, with a high near 30. Overnight low around 18.
Saturday: Mostly cloudy, with a high near 28. Overnight low around 10.
Sunday: Partly sunny, with a high near 17. Overnight low around 3.
Forecast provided by the National Weather Service at Wilmington.