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Related video above: People on the move this Memorial Day weekend

Travel is up, COVID-19 cases are down and vaccines have been put in many arms.

The coronavirus pandemic isn't over, but Memorial Day weekend is set to look more like it did before the virus upended life more than a year ago.

Americans Saturday were experiencing their first holiday weekend since the CDC changed its masking guidance on May 13 -- that fully vaccinated people don't need to wear masks indoors, and they don't have to keep their distance from others.

Mask mandates melted away. As of Friday, California, Hawaii, New Mexico were the only states with mask mandates for everyone.

People are increasingly on the move. AAA estimated that more than 37 million people in the U.S. will travel at least 50 miles from home over the Memorial Day weekend -- 13% down from 2019, but 60% above last year.

And the U.S. set a pandemic-era record number of passengers traveling through U.S. airports in a single day -- 1.96 million -- on Friday, according to the Transportation Security Administration.

President Joe Biden on Friday praised what vaccination progress has been made, expressing a sense of hope ahead of the unofficial start of summer.

"We're not just saving lives. We're getting our lives back, " Biden said during remarks at Sportrock Climbing Center in Alexandria, Virginia on Friday.

Vaccines have helped make a gradual return to normalcy possible.

More than 166 million people in the U.S. -- 50.1% of the population -- have received at least one dose of a COVID-19 vaccine as of early Friday, according to the U.S. Centers for Disease Control and Prevention.

Cases have fallen since a short rise in mid-April: The country has averaged more than 21,600 COVID-19 cases a day over the past week -- 69% below the spring 2021 peak of more than 71,200 on April 14, according to Johns Hopkins University data.

Last year, public health specialist Dr. Saju Mathew was worried about case spikes that followed holiday travel and congregating.

"This year I am not as worried. What a difference these vaccines have made," Mathew, a primary care physician in Atlanta, told CNN on Saturday.

But with mask mandates evaporating -- and maybe with unvaccinated people dropping their masks against CDC guidance -- the unvaccinated "have become more of a threat to each other," he said.

"All the more reason I hope the unvaccinated crowd will get that incentive to get vaccinated," Mathew said.

The CDC on Thursday predicted that daily cases, hospitalizations and deaths will fall over the next four weeks. The CDC ensemble forecasts concluded that there will be a total of 596,000 to 606,000 COVID-19 deaths by June 19.

As of Friday, COVID-19 has killed at least 593,364 people and infected more than 33 million in the U.S., according to Johns Hopkins.

Most seniors are vaccinated

The improved outlook is boosted by continuing efforts by states to get people vaccinated. Already, 10 states have reached the Biden administration's goal of vaccinating 70% of adults by July 4 with at least one dose.

Also, nearly three-quarters of seniors are now fully vaccinated, according to CDC data.

On Friday, Biden said despite the growing light at the end of the tunnel, "We're not done yet."

"We have to reach those who are not vaccinated and make it as easy as possible for them to get protected," he said.

Meanwhile, in Georgia, Republican Gov. Brian Kemp signed an executive order prohibiting schools and school districts from requiring students and workers to wear a face covering while on campus.

The new order, effective Monday, also eliminates rules for restaurants, bars, conventions, child care facilities, live performance venues and other organizations. Previous executive orders eliminated regulations for camps and sporting events, according to a press release.

"As hospitalizations, cases, deaths, and percent positive tests all continue to decline -- and with vaccinations on the rise -- Georgians deserve to fully return to normal," Kemp said in the release. "With safe and effective vaccines widely available and the public well-aware of all COVID-19 mitigation measures, mandates from state and local governments are no longer needed."

Vaccine disparities continue in America's vulnerable communities

The slow return to normalcy is made possible by vaccines, and those who choose to take them. But there is a segment of the U.S. population that is not getting vaccinated as quickly, and it's not all by choice.

Socially vulnerable counties in America are experiencing lower vaccination rates, according to CDC data published Friday.

A CNN analysis of the federal data found counties that are lagging behind the overall COVID-19 vaccination rate tend to be poorer and less educated, with less access to computers and the internet.

This digital and economic divide contributes to disparities in health care access generally, experts say, and access to COVID-19 vaccines is no exception.

"With too many things in health, we focus on the individual behavior without looking at the systems that either make it easy or not for someone to practice that healthy behavior," Dr. Richard Besser, president and chief executive officer of the Robert Wood Johnson Foundation, told CNN.

The CDC used a social vulnerability index, which assesses counties based on 15 factors in four categories: socioeconomic status, household composition, race and ethnicity, and housing type and transportation. More vulnerable counties have been disproportionately affected by the COVID-19 pandemic, but those same communities have also lagged in vaccination rates.

"Health behaviors (like getting a COVID-19 vaccine) are, in part, a personal choice," Besser said. "But one of the things that's often said is that the choices we make depend on the choices that we have. For someone who doesn't have internet access, there's not much choice there in being able to go online and schedule your appointment."

Another health crisis?

As the nation inches toward the possible end of the pandemic, another health crisis looms.

It's time to address the loneliness epidemic, U.S. Surgeon General Dr. Vivek Murthy said Friday.

"At the heart of all of this is a bigger, deeper question that we have an opportunity to address right now -- which affects our mental health ... which is a question of what kind of society do we want to design after this pandemic ends?" Murthy said during a federal health meeting.

Loneliness can lead to anxiety and depression as well as sleep disturbances, dementia and shorter lifespans, Murthy said.

Not to mention the toll that racism and xenophobia can have on one's mental health, chipping away at people's self-worth and making "them feel like outsiders," he said.

"It contributes to a sense of isolation," Murthy noted.

With an unsurprising boost in travel this Memorial Day weekend, many businesses are preparing to welcome customers in their stores for the holidays. But for two co-owners of a business in Ellicott City, Maryland, the holiday has much deeper meaning.In Old Ellicott City, there's one shop on Main Street whose two owners witnessed from the battlefield fellow comrades in war that paid the ultimate sacrifice for the United States."Instead of concentrating on what we were doing at the time to get us out of that mindset, we thought about the business, came up with the name, the logo," said Julio Alegria, co-owner Gamers Corps.That's why for the co-owners of Gamers Corps, Memorial Day isn't just a day for traveling, but to educate through their business."Having deployed to combat five separate times myself to both Iraq and Afghanistan, I know several, if not dozens, of Marines, soldiers, sailors, airmen that never got to come home," said Marine Master Sgt. Tim McManus and co-owner of Gamers Corps.As businesses on Main Street prepare for the holiday weekend, one economist told sister station WBAL that this Memorial Day could be a much needed rebound for the entire state."Obviously, our hospitality and tourism sector are probably poised to recover partially from last year obviously, dining establishments are going to see a big boost. Some of the sporting venues are going to see a big boost in attendance," said Daraius Irani, chief economist of RESI at Towson University.And while many are traveling to the beaches or plan to enjoy some outdoor cooking, the events underway at the gaming shop are more than just a boost for their own business this weekend, but a way to honor the soldiers who aren't here by keeping their memories alive even if it's through gaming."For us, it means just to bring the community together," Alegria said."I think a lot of people need to take a second, if not a minute, to remember that the reason that they have the day off, the reason that they are going to a barbecue, or beach is not just to be with family and celebrate that they're off from work. Memorial Day is for those who have fallen and didn't get to come back," McManus said.