Grace Thomas is fully vaccinated against COVID-19 but still not ready to take off her mask, especially around the kids at the home day care she runs in Chicago.

But whether the children continue to wear masks remains to be seen after the Centers for Disease Control and Prevention announced that healthy people in most areas of the country can safely stop wearing masks as cases continue to fall.

Thomas, 62, plans to ask parents to have their children wear masks to prevent the day care from being a potential source of transmission, but "you can’t make them wear masks if they don’t want to," she said.

Many Americans, including parents of school children, have been clamoring for an end to masking while others remain wary that the pandemic could throw a new curveball. Now, states, cities and school districts are assessing Friday's guidance to determine whether it’s safe to stop mask-wearing — long after others threw out such mandates and many Americans ignored them.

Illinois Gov. J.B. Pritzker said that the statewide school mask mandate will be lifted Monday in response the the new guidance, although Chicago Public Schools officials said they will continue to require masks "to maintain health and safety measures."

Los Angeles on Friday began allowing people who are vaccinated to remove their masks indoors, and Washington, D.C., had already said it would end its mask mandate on Monday. Washington state and Oregon plan to lift indoor mask mandates in late March.

But the issue still remains politically fraught: Florida’s governor on Thursday announced new recommendations called "Buck the CDC" that discourage mask wearing — even though the CDC says the state still has wide areas at high levels of concern.

Christine Bruhn, 79, a retired food science professor at the University of California at Davis, said she’ll only take off her mask if she thinks it’s safe, usually around vaccinated friends. When she’s around a large group of strangers, "I’m wearing a mask," Bruhn said.

"I have been vaccinated and boosted but I don’t want to get sick," said Bruhn, who also said she'll continue crossing the street to keep her distance from people without masks if she sees any of them walking toward her.

American Medical Association President Gerald E. Harmon said Friday that he would continue to wear a mask in indoor public settings and urged "all Americans to consider doing the same" because millions are susceptible to severe illness or too young to be vaccinated.

Still, many people appear to be done with masking.

Steve Kelly, a manager of Kilroy’s Bar & Grill in downtown Indianapolis, said it seems that neither employees nor customers think much about COVID since Indiana lifted a mask mandate for restaurants.

"It doesn’t seem like anybody is wearing masks," he said of his customers, though a few employees still do. And he said people rarely get upset anymore.

"My daughter is 13 and she wears a mask. It’s her choice," he said. "Nobody bothers her about it and she wouldn’t care if they did."

In central Illinois' Effingham County, mask-wearing — and the animosity between those who do and don't — has plummeted, said David Campbell, vice chairman of the county board. He said about the only places he sees people wearing masks are hospitals and doctors’ offices.

"Eighty-five to ninety percent of the people you see on the street, in stores, restaurants, aren’t wearing them," said Campbell, 61. "You used to hear people say, ‘Why aren’t you wearing masks?’ but you don’t anymore."

Under the new guidance, the CDC says people can stop wearing masks if they live in counties where the coronavirus poses a low or medium threat to hospitals — accounting for more than 70% of the U.S. population.

The agency still advises people, including schoolchildren, to wear masks where the risk of COVID-19 is high, in about 37% of U.S. counties, where about 28% of Americans live. And those with COVID-19 symptoms or who test positive should wear masks, the agency said.

The recommendations do not change the requirement to wear masks on public transportation and in airports, train stations and bus stations, but the guidelines for other indoor spaces aren’t binding, meaning cities and institutions may set their own rules.

Two of the nation’s largest teachers unions weighed in, with American Federation of Teachers President Randi Weingarten calling the guidance "long-needed new metrics for a safe off-ramp from universal masking." She said many students and teachers have struggled with COVID-19 restrictions.

But National Education Association President Becky Pringle urged school districts to "act cautiously" and seek input from local educators before making any decisions to end mask-wearing.

Chicago high school teacher Sharon Holmes said she'll continue to wear a mask while teaching and outside the classroom.

"My partner and my daughter both have asthma," said the 53-year-old Holmes. "I just don’t feel safe yet, personally."

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Webber reported from Fenton, Michigan.

The director of the CDC has suggested that the health agency could soon issue a new mask guidance during a news briefing Wednesday.

The change could be announced as soon as next week, as White House officials asked Walensky to provide an update by March 1, before the president’s State of the Union Address.

Dr. Rochelle Walensky suggested the mask recommendations would be based on a community’s hospitalization rates.

She added that this would allow people to take a break from wearing masks when COVID-19 case numbers improve.

However, this would not be a permanent change.

If a community’s case numbers spike up, masks will have to go back on.

Walensky said Wednesday that people should still continue to wear masks in certain situations, including when people are symptomatic or are within ten days of positive diagnosis.

The agency is still working out the details of when masks are and are not necessary.

The change in guidance will come as a number of states announce their own modifications to COVID-19 safety measures.

Last week, ten states announce they were lifting mask mandates in indoor spaces and/or schools.

Dr. Anthony Fauci has expressed support in allowing states to make these changes as cases decrease.

“At the local level, there is a strong feeling of need to get back to normality,” said Fauci on MSNBC.

For Americans vaccinated against COVID-19, daily life may look increasingly different than for those who aren't inoculated yet following Thursday's mask guidance, experts said.

"We are on the right path (for) people who are fully immunized," National Institutes of Health Director Dr. Francis Collins told CNN. "You can take your mask off indoors as well as outdoors."

But he added: "We are not at the end of this story. There are still a lot of people who haven't gotten that shot."

The Centers for Disease Control and Prevention announced that people fully vaccinated against COVID-19 — meaning those who have waited two weeks after their final dose — generally don't need to wear masks or practice social distancing indoors or outdoors.

The CDC arrived at its new guidance because of declining case rates, increasing numbers of vaccinations and growing understanding of the risk of viral spread by vaccinated people, CDC Director Dr. Rochelle Walensky told CBS on Friday.

"In the last two weeks, our cases have come down by a third," she said. "We have a rapidly declining case right probably because our vaccination rate is going up.

"Over the last several weeks, we have seen emerging signs that if you were vaccinated, you're safe and protected from getting COVID-19 and you really have a very low risk of transmitting to other people and that these vaccines are really working against the variants that we have circulating here in the United States," she said.

For those who experienced no immediate impact from receiving their vaccine, "now your life is going to change," said Dr. Anthony Fauci, adding that although some businesses, like airlines, may keep mask mandates in place, venues like grocery stores, restaurants, bars and bowling alleys may soon look much more like they did pre-pandemic.

The CDC's decision may have the indirect effect of being an incentive for people who are on the fence about getting the vaccine, but it was based on the science showing how strong vaccine protection is, Fauci said.

But as a sense of normalcy resumes for those who are protected, experts warn that the risk of infection may grow for those who are not vaccinated.

"We keep thinking of this country as a vaccinated and an unvaccinated country," CNN medical analyst Sanjay Gupta said. "What it's slowly going to turn into is a vaccinated and an infected country."

And without a way to verify who is vaccinated and who is not, the guidance may inhibit the U.S. from reaching herd immunity and put those who cannot yet be vaccinated or are immuno-compromised in more danger, said CNN medical analyst Leana Wen.

"They were overly cautious and now I think they are throwing caution to the wind," Wen said of the CDC's guidelines.

People should defer to local rules on mask-wearing, Walensky told NBC on Friday.

"We really do need to understand that this country is not uniform. There are places in this country that still have higher rates of disease. There are places in this country that still have lower rates of vaccination," she said.

"People need to look into their local environment because, ultimately, we know that this virus is an opportunist, and where there are low rates of vaccination, it will emerge again," Walensky said. "We really need to make sure that we get people vaccinated, and we still continue to take precautions if people are not vaccinated."

Masks may stay on for some

Those who are not vaccinated are threatening their own health if they go out in public and forego the social-distancing and mask usage guidance, experts said.

And people who have compromised immune systems from situations like chemotherapy and organ transplants may not have a sufficient immune response to safely remove their masks in public, Wen said.

Although studies are ongoing for younger children, vaccines have only been approved for children as young as 12. So, those who are not yet old enough to get their doses still need to wear their masks indoors and around others, Fauci said.

Elementary age children likely won't be vaccinated until the end of the year, Fauci told MSNBC on Friday.

"They're called age de-escalation studies, and that is you get children at different age brackets, and you do a test to make sure that it's safe," he said. "You go from age 12 to 9. if it looks good, then you go 9 to 6; that looks good, 6 to 2; that looks good, and then 6 months to 2 years."

That timeline likely puts the youngest children at the back of the line, Fauci said.

"I think that high school kids, adolescents certainly, will be able to be vaccinated by the time we get to the fall year, but I think it's going to take to the end of the calendar year to get elementary."

U.S. retailers may still require patrons be masked, and the CDC still advises wearing one when traveling or using public transport, Walensky noted.

The choice to remove masks is a decision vaccinated people can make for themselves, and some may choose not to, Fauci said.

"There's absolutely nothing wrong with an individual who has a certain level of risk aversion, as we know the risk is extremely low of getting infected whether you're indoors or outdoors," Fauci said. "But there are those people who don't want to take that bit of a risk, and there's nothing wrong with that, and they shouldn't be criticized."

Some states jump on the changes, others hold back

How the recommendations play out may depend on how state leaders respond— and their reactions have been varied.

Michigan Gov. Gretchen Whitmer announced Friday the state will lift its mask requirement for fully vaccinated people effective Saturday at 9 a.m., according to a statement released by her office.

"The vast majority of us have trusted the scientists and experts to keep us safe during the pandemic, and it has worked. With millions of Michiganders fully vaccinated, we can now safely and confidently take the next step to get back to normal," Whitmer said.

Maryland, Minnesota, New Mexico, Vermont and Virginia are ending mask mandates for vaccinated people, effective Friday, May 14. Delaware will lift its mask mandate for the vaccinated on May 21.

In Virginia, all distancing and capacity restrictions will be lifted May 28, two weeks earlier than planned, Gov. Ralph Northam said Friday.

Kentucky Gov. Andy Beshear said that capacity restrictions and face mask mandates will end June 11 and "life will be almost fully back to normal."

West Virginia Gov. Jim Justice said he will lift the state's face mask requirements for fully vaccinated people on June 20.

Rhode Island will align its mask guidance with the CDC's starting Tuesday, Gov Dan McKee said Friday, and Ohio Gov. Mike DeWine directed the state's health department to conform the state's health order with the CDC's guidance.

Alabama Gov. Kay Ivey called the latest guidance "common sense" and said the state has "already embraced this idea," in a statement to CNN. Alabama dropped the state's mask mandate in April.

"Alabamians are getting back to living. So, Alabama, roll up your sleeves and get the vaccine!" Ivey said.

New York, Colorado and North Carolina officials will review the guidance before making any changes.

Los Angeles County has decided against following the new relaxed measures for now.

While vaccinated people don't need to wear a mask in the company of other vaccinated people in uncrowded areas, everybody is still required to wear face coverings in crowded indoor and outdoor venues, Public Health Director Barbara Ferrer said Thursday during a news conference.