A federal appeals court panel has ruled that President Joe Biden's vaccine mandate for larger private employers can take effect.

Friday's 2-1 ruling from a panel of judges on the 6th U.S. Circuit Court of Appeals reverses a lower-court ruling that had paused the requirement.

Republican-led states are challenging the rule, which would apply to companies with at least 100 workers.

It was initially planned to take effect on Jan. 4, but it's not clear now when it might.

South Carolina Attorney General Alan Wilson says the fight against the mandate will continue.

According to the Associated Press, companies with 100 or more employees would be affected by the vaccine requirement, covering about 84 million workers. 

Those unvaccinated would have to wear masks and be subject to testing weekly for coronavirus.

Those who work outdoors or at home could have exceptions.

The Los Angeles City Council passed an ordinance Wednesday that will require proof of complete vaccination for indoor spaces.

The ordinance, which is considered on the country's strictest vaccine mandates, begins on Nov. 4.

The LA Times reported the mandate passed with 11 votes, just short of the 12 votes needed to pass with an urgency clause allowing it to take effect immediately.

According to the Associated Press, the new mandate requires everyone to be fully vaccinated to enter bars, restaurants, nail salons, gyms, or even Los Angeles Lakers games.

Per the news outlet, Mayor Eric Garcetti is expected to sign the ordinance into law.

Those with religious or medical exemptions for vaccinations must test negative for the virus 72 hours before entering the establishments.